OriginalArticle
Stressdistributioninthewallsofmajorarteries:implicationsforatherogenesisSiamakMishani1,HananeBelhoul-Fakir2,ChrisLagat1,ShirleyJansen3,4,5,6^,BrianEvans1,MichaelLawrence-Brown2
1WASchoolofMines:MECE,FacultyofScienceEngineering,CurtinUniversity,Kensington,WA,Australia;2SchoolofPublicHealth,FacultyofHealthSciences,CurtinUniversity,Nedlands,WA,Australia;3VascularSurgeryCurtinMedicalSchool,CurtinUniversity,Perth,WA,Australia;4DepartmentofVascularandEndovascularSurgery,SirCharlesGairdnerHospital,Perth,WA,Australia;5HeartandVascularResearchInstitute,HarryPerkinsInstituteforMedicalResearch,Perth,WA,Australia;6UniversityofWesternAustralia,Crawley,WA,Australia
^ORCID:---.
Correspondenceto:ShirleyJansen.DepartmentofVascularandEndovascularSurgery,SirCharlesGairdnerHospital,6thFloorGBlock,Nedlands,Perth,WA,Australia.Email:shirley.jansen
health.wa.gov.au.Background:Thereisacorrelationbetweenthesitesofatheromadevelopmentandstresspointsinthearterialsystem.Generally,pulsepressureresultsinstressesactingonthevascularvessel,includinglongitudinalstress,radialornormalstress,tangentialstressorhoopstressandshearstress.Thispaperexplorestherelationshipbetweenarterialwallshearstressandpulsatilebloodpressurewiththeaimoffurtheringtheunderstandingofatherogenesisandplaqueprogression.
Methods:We